A General Method for Conditional Regulation of Protein Stability in Living Animals
نویسندگان
چکیده
منابع مشابه
A general method for conditional regulation of protein stability in living animals.
The ability to rapidly and reversibly perturb protein levels in living animals is a powerful tool for researchers to determine protein function in complex systems. We recently designed a small protein domain based on the 12-kDa FKBP (FK506 binding protein) that can be fused at either the carboxyl or amino terminus of a protein of interest. This destabilization domain (DD) confers instability to...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Protocols
سال: 2009
ISSN: 1559-6095
DOI: 10.1101/pdb.prot5173